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AviClear® VS Roaccutane and Accutane Medication for Acne Treatment

Explore the difference between isotretinoin and the revolutionary AviClear acne treatment

Acne vulgaris, a common and often stubborn skin condition, affects millions worldwide, with profound impacts on self-esteem and quality of life. Traditional acne treatments, such as Roaccutane (isotretinoin) and Accutane (a brand name of isotretinoin), have been widely used for severe cases of acne. However, these medications come with a host of potential side effects that can be difficult to manage. Enter AviClear, a novel laser-based acne treatment that offers a promising alternative.

This blog will compare AviClear to isotretinoin-based treatments, highlighting the benefits and drawbacks of each to help you make an informed decision for your acne treatment journey.

What We‘ll Cover:

Understanding Isotretinoin-Based Acne Treatments

How it works

Isotretinoin, the active ingredient in both Roaccutane and Accutane, is a potent oral medication primarily prescribed for severe or cystic acne that has not responded to other treatments. It works by reducing the size and output of sebaceous glands, decreasing the amount of oil produced by the skin, and inhibiting the growth of acne-causing bacteria.

Side Effects and Considerations

While isotretinoin is highly effective, it is also associated with numerous potential side effects, which can range from mild to severe. Common side effects include dry skin, lips, and eyes; nosebleeds; and sensitivity to the sun. More serious risks involve liver damage, elevated cholesterol levels, and mental health issues such as depression and anxiety. Women of childbearing age must also adhere to strict contraceptive measures due to the high risk of severe birth defects.

Treatment Duration and Outcomes

A typical course of isotretinoin treatment lasts between 4 to 6 months. Many patients experience significant and often long-term improvement in their acne. However, some may require additional courses of treatment, and there is a risk of relapse, particularly in individuals with hormonal acne or those who do not adhere to the prescribed regimen.

On Accutane for 9 months

Photo Courtesy of Cosmopolitan.

11 months post-Accutane

Photo Courtesy of Cosmopolitan.

Introducing AviClear: The Modern Approach to Acne Treatment

AviClear utilises a revolutionary 1726-nm laser that specifically targets and reduces sebaceous gland activity without the systemic side effects associated with oral medications. The precision of AviClear allows it to effectively treat acne at its source, reducing inflammation and preventing future breakouts. This non-invasive treatment offers a significant advantage for those who are concerned about the long-term implications of systemic drugs.

Learn more.

Photo Courtesy of Cutera.

"AviClear machine used for acne treatments at Sharkra Medi Spa in Hobart"

Photo Courtesy of Cutera.


How it works

Clinical Efficacy

According to clinical trials, AviClear has demonstrated significant improvements in acne severity.

Clinical Trial Overview:

  • The AviClear trial included 104 patients with moderate-to-severe acne.
  • Participants received three 30-minute treatments at 2-to-5-week intervals.


  • Significant improvements were observed in both inflammatory lesion count (ILC) and investigator global assessment (IGA).
  • Follow-up data at 12, 26, and 52 weeks showed sustained improvement in IGA and a reduction in comedones and inflammatory lesions .

Safety and Tolerability

AviClear is generally well-tolerated, with the most common side effects being mild, such as redness and swelling at the treatment site. Pain management strategies, such as the use of acetaminophen and ibuprofen, can mitigate discomfort during the procedure. Importantly, AviClear does not carry the same systemic risks as isotretinoin, making it a safer option for a broader range of patients, including those who cannot or prefer not to take oral medications .

Long-Term Benefits and Considerations

One of the notable benefits of AviClear is its ability to reduce oiliness, a common contributing factor to acne, for up to a year post-treatment. This can significantly enhance overall skin health and appearance. Additionally, AviClear is suitable for both adults and adolescents 16+. The treatments efficacy in reducing comedones and inflammatory lesions makes it a comprehensive solution for various types of acne .

Photo Courtesy of AviClear.

Comparing AviClear and Roaccutane/Accutane Acne Treatments


Both AviClear, Roaccutane and Accutane (isotretinoin) are effective for treating severe acne. Isotretinoin offers rapid and profound results, often providing long-term remission. However, AviClear presents a non-invasive alternative with comparable efficacy, particularly for patients seeking to avoid the systemic side effects of oral medications.

Safety Profile

The safety profile of AviClear is significantly more favourable compared to isotretinoin.

Isotretinoin’s extensive list of potential side effects requires close medical supervision and strict precautions, especially for women of childbearing age.

In contrast, AviClear’s localised approach minimises the risk of systemic complications, making it a safer option for many patients.

Treatment Experience

Isotretinoin requires daily oral administration over several months, accompanied by regular monitoring of blood tests and potential side effects.

AviClear, on the other hand, involves a series of in-clinic treatments with minimal downtime and fewer long-term management requirements.

The convenience and reduced burden of side effects make AviClear an attractive option for those with busy lifestyles or concerns about medication adherence.


In the evolving landscape of acne treatment, both AviClear, Roaccutane and Accutane have their place. Isotretinoin remains a powerful option for severe, unmanageable acne but comes with significant risks and side effects. AviClear offers a cutting-edge, non-invasive alternative with a favourable safety profile and effective results, making it a compelling choice for many patients.

If you are considering your options for acne treatment and want to explore the benefits of AviClear, we invite you to visit our clinic and book a consultation. Take the first step towards clearer skin and improved confidence today.

Book a Consultation and start your AviClear journey with us


  • Goldberg D, Kothare A, Doucette M, Kaur A, et al. Selective photothermolysis with a novel 1726 nm laser beam: A safe and effective solution for acne vulgaris. J Cosmet Dermatol 2023;22(2):486-496.
  • Tan J, Kang S, Leyden J. Prevalence and risk factors of acne scarring among patients consulting dermatologists in the United States. J Drugs Dermatol. 2017;16(2):97-102.
  • Gold MH. Therapeutic and aesthetic uses of photodynamic therapy part two of a five-part series: lasers and light treatments for acne vulgaris promising therapies. J Clin Aesthet Dermatol 2008;1(3):28-34.
  • Goldberg D, Andriessen A, Bhatia A, Gold M, et al. Treatment of mild to severe acne with 1726 nm laser: A safe alternative to traditional acne therapies. J Cosmet Dermatol 2023;22(11):3026-3032.
  • “The Dermatology Digest,” pages 36-37. This document provides a comprehensive overview of AviClear, including its clinical trials, efficacy, and usage guidelines.

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